Personal Note From Patrick, The Editor

HiReader, when was the last time you were truly inspired?

Today, I hope to bring you a sense of hope and aspiration regarding sustainable practices.

We will take a look at some astonishing advancements in instrument efficiency.

So, let us dive in and explore what innovation looks like!

Number Of The Day

The Scientific Instruments Market Size in 2024 was estimated at 40 billion US dollars. After significant growth in past years, projections extrapolate a market size exceeding 60 billion by 2030! Undoubtedly, AI and automation will continue to drive this development. However, will we see sustainable innovations in a similar fashion?

40 Billion

The Sustainability of Equipment

To judge the sustainability of our equipment, we need to consider:

• Sufficiency & Breadth of Performance
• Running Efficiency (e.g., energy consumption and heat generation)
• Type and Volume of Required Reagents (including sample preparation)
• By-products and Waste Generation (from reagents and samples)
• Embodied Carbon of the Material

Normally, marketing focuses solely on performance, but let us explore some of the most astonishing opportunities to make equipment more sustainable.

Mass Spectrometry

Some MS systems use nitrogen to remove solvent from ions in the ionization source. More efficient source design and optimized desolvation processes can reduce this consumption.

For instance, Water's ESI mass spectrometers use a gas flow of 20–23 L/min, compared to other systems that use up to 77 L/min. In fact, older instruments consume a liquid nitrogen even in “standby.”

At first glance, these numbers might seem irrelevant, but:

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In core facilities, instruments will probably run for 8h each working day. Being conservative we assume 200 workdays.

In many industry settings instruments run 24/7. However, let us assume just 20 hours of active use and 10 days for service and repair:

The 70% higher efficiency translates to unimaginable savings of

2.5 million liters (academic) or 23 million liters (industry)

of nitrogen per year per machine!

Huge shout out to Gunnar Weibchen and Claudia Rathmann from Waters for their engagement and support in this topic!

High-Performance Liquid Chromatography (HPLC)

In HPLCs, we find a number of innovations. From solid-core particles that enable more efficient separations and up to a 50% reduction in run time, which equates to 50% less solvent use and energy consumption in contrast to fully porous silica particles.

A similar reduction can be achieved by halving column length and particle size while keeping the flow rate constant.

However, one of the most exciting advancements is the use of modern low-dispersion systems. Many LC-UV instruments still use 4.6-mm inner diameter (i.d.) columns, but switching to 2.1-mm i.d. columns can reduce solvent consumption by up to 80%. For a more forgiving option, 3.0-mm i.d. columns save about 60% of mobile phase use.

Considering that approximately 150 million kilograms of methanol and acetonitrile are used annually, these changes could save 50 million kilograms—the equivalent of 10 Eiffel Towers in weight!

Flow Cytometry

Unfortunately, information about sustainability improvements in flow cytometry is sparse. Nevertheless, the Attune NxT Flow Cytometer provides a newsworthy example:

Conventional flow cytometers require large volumes of fluid and compromise resolution when increasing the sample flow rate.

The Attune NxT, using an acoustic field in its hydrodynamic system, addresses these challenges:

• It generates 1.8 L of biological waste per day, compared to up to 20 L from conventional systems.
• It enables adjustable flow rates of up to 1 mL/min, allowing for dilute samples and less starting material.
• The acoustic focusing system facilitates no-wash, no-lyse methods, reducing prep time from 65–130 minutes to 20–40 minutes.

These advancements mean less solvent use upfront and more than 90% savings in hazardous fluid generation.

Applying The Knowledge

When selecting a new instrument, our considerations should go beyond just performance.

Sample preparation requirements is an often underappreciated factor both in terms of process optimization as well as sustainability.

Increasing processing speed enhances efficiency but also carries compound effects. Faster operations consume less energy and generate less heat, thereby reducing HVAC demands.

Therefore, pay attention that even in the high-performance segments, significant sustainability differences exist. And to make you aware of those ReAdvance exists ; )

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How We Feel Today

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Edited by Patrick Penndorf
Connection@ReAdvance.com
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